Detailed information of TA system TA191350

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3510742..3511000
• Replicon: chromosome
• Accession: NZ_CP069627
• Organism: Escherichia coli strain ESM1.4

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JSQ89_RS16695
• Protein ID: WP_000809168.1
• Coordinates: 3510742..3510894 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3510943..3511000 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSQ89_RS16675	3505987..3506700	-	714	WP_001102391.1	acidic protein MsyB	-
JSQ89_RS16680	3506726..3507130	-	405	WP_000843687.1	DUF2541 family protein	-
JSQ89_RS16685	3507502..3509418	+	1917	WP_000516135.1	molecular chaperone DnaK	-
JSQ89_RS16690	3509507..3510637	+	1131	WP_001118465.1	molecular chaperone DnaJ	-
JSQ89_RS16695	3510742..3510894	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3510943..3511000	+	58	-	-	Antitoxin
JSQ89_RS16700	3511509..3512270	+	762	WP_001274832.1	outer membrane protein OmpK	-
JSQ89_RS16705	3512290..3513783	+	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
JSQ89_RS16710	3513912..3515171	+	1260	WP_000494928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T191350 WP_000809168.1 NZ_CP069627:c3510894-3510742 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T191350 NZ_CP091682:c4044068-4043754 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT191350 NZ_CP069627:3510943-3511000 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin