Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 85657..85926 Replicon plasmid unnamed1
Accession NZ_CP069590
Organism Escherichia coli strain FDAARGOS_1266

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag I6J96_RS25145 Protein ID WP_001312861.1
Coordinates 85768..85926 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 85657..85722 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J96_RS25115 81450..81977 + 528 WP_000290793.1 single-stranded DNA-binding protein -
I6J96_RS25120 82033..82266 + 234 WP_000006004.1 DUF905 domain-containing protein -
I6J96_RS25125 82325..84283 + 1959 WP_001145469.1 ParB/RepB/Spo0J family partition protein -
I6J96_RS25130 84338..84772 + 435 WP_000845901.1 conjugation system SOS inhibitor PsiB -
I6J96_RS25135 84769..85488 + 720 WP_001276234.1 plasmid SOS inhibition protein A -
I6J96_RS25140 85500..85688 - 189 WP_001299721.1 hypothetical protein -
- 85500..85724 + 225 NuclAT_0 - -
- 85500..85724 + 225 NuclAT_0 - -
- 85500..85724 + 225 NuclAT_0 - -
- 85500..85724 + 225 NuclAT_0 - -
- 85657..85722 - 66 - - Antitoxin
I6J96_RS25145 85768..85926 + 159 WP_001312861.1 type I toxin-antitoxin system Hok family toxin Toxin
I6J96_RS25150 86845..87132 + 288 WP_000107537.1 hypothetical protein -
I6J96_RS25155 87253..88074 + 822 WP_204097655.1 DUF945 domain-containing protein -
I6J96_RS25160 88371..89018 - 648 WP_000614282.1 transglycosylase SLT domain-containing protein -
I6J96_RS25165 89304..89687 + 384 WP_001151564.1 relaxosome protein TraM -
I6J96_RS25170 89881..90567 + 687 WP_000332487.1 PAS domain-containing protein -
I6J96_RS25175 90661..90888 + 228 WP_001254388.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(6')-Ib-cr / blaOXA-1 / blaTEM-1B / tet(A) / blaCTX-M-15 - 1..127965 127965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-48)


Sequences


Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T191071 WP_001312861.1 NZ_CP069590:85768-85926 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T191071 NZ_CP091634:317650-318003 [Salmonella enterica]
ATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGGCATGCCTGATCCTGG
GCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGTGGCTGCTGGCGGCAA
TGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTTATTACGCTGCTGTTT
TTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGCGGCAGGGCGGCTTAC
GCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 66 bp

>AT191071 NZ_CP069590:c85722-85657 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB P11895


Antitoxin

Download structure file

References