Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 85657..85926 | Replicon | plasmid unnamed1 |
Accession | NZ_CP069590 | ||
Organism | Escherichia coli strain FDAARGOS_1266 |
Toxin (Protein)
Gene name | hok | Uniprot ID | P11895 |
Locus tag | I6J96_RS25145 | Protein ID | WP_001312861.1 |
Coordinates | 85768..85926 (+) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 85657..85722 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6J96_RS25115 | 81450..81977 | + | 528 | WP_000290793.1 | single-stranded DNA-binding protein | - |
I6J96_RS25120 | 82033..82266 | + | 234 | WP_000006004.1 | DUF905 domain-containing protein | - |
I6J96_RS25125 | 82325..84283 | + | 1959 | WP_001145469.1 | ParB/RepB/Spo0J family partition protein | - |
I6J96_RS25130 | 84338..84772 | + | 435 | WP_000845901.1 | conjugation system SOS inhibitor PsiB | - |
I6J96_RS25135 | 84769..85488 | + | 720 | WP_001276234.1 | plasmid SOS inhibition protein A | - |
I6J96_RS25140 | 85500..85688 | - | 189 | WP_001299721.1 | hypothetical protein | - |
- | 85500..85724 | + | 225 | NuclAT_0 | - | - |
- | 85500..85724 | + | 225 | NuclAT_0 | - | - |
- | 85500..85724 | + | 225 | NuclAT_0 | - | - |
- | 85500..85724 | + | 225 | NuclAT_0 | - | - |
- | 85657..85722 | - | 66 | - | - | Antitoxin |
I6J96_RS25145 | 85768..85926 | + | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
I6J96_RS25150 | 86845..87132 | + | 288 | WP_000107537.1 | hypothetical protein | - |
I6J96_RS25155 | 87253..88074 | + | 822 | WP_204097655.1 | DUF945 domain-containing protein | - |
I6J96_RS25160 | 88371..89018 | - | 648 | WP_000614282.1 | transglycosylase SLT domain-containing protein | - |
I6J96_RS25165 | 89304..89687 | + | 384 | WP_001151564.1 | relaxosome protein TraM | - |
I6J96_RS25170 | 89881..90567 | + | 687 | WP_000332487.1 | PAS domain-containing protein | - |
I6J96_RS25175 | 90661..90888 | + | 228 | WP_001254388.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | aac(6')-Ib-cr / blaOXA-1 / blaTEM-1B / tet(A) / blaCTX-M-15 | - | 1..127965 | 127965 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 6082.32 Da Isoelectric Point: 9.2584
>T191071 WP_001312861.1 NZ_CP069590:85768-85926 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 159 bp
>T191071 NZ_CP091634:317650-318003 [Salmonella enterica]
ATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGGCATGCCTGATCCTGG
GCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGTGGCTGCTGGCGGCAA
TGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTTATTACGCTGCTGTTT
TTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGCGGCAGGGCGGCTTAC
GCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA
ATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGGCATGCCTGATCCTGG
GCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGTGGCTGCTGGCGGCAA
TGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTTATTACGCTGCTGTTT
TTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGCGGCAGGGCGGCTTAC
GCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA
Antitoxin
Download Length: 66 bp
>AT191071 NZ_CP069590:c85722-85657 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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