Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2715998..2716797 Replicon chromosome
Accession NZ_CP069589
Organism Escherichia coli strain FDAARGOS_1266

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag I6J96_RS13415 Protein ID WP_000347251.1
Coordinates 2716333..2716797 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag I6J96_RS13410 Protein ID WP_001296435.1
Coordinates 2715998..2716333 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J96_RS13395 2711783..2712553 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
I6J96_RS13400 2712569..2713903 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
I6J96_RS13405 2714278..2715849 + 1572 WP_001273763.1 galactarate dehydratase -
I6J96_RS13410 2715998..2716333 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
I6J96_RS13415 2716333..2716797 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
I6J96_RS13420 2716852..2717661 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
I6J96_RS13425 2717910..2719190 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
I6J96_RS13430 2719213..2719686 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
I6J96_RS13435 2719697..2720476 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
I6J96_RS13440 2720466..2721344 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
I6J96_RS13445 2721362..2721796 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T191054 WP_000347251.1 NZ_CP069589:2716333-2716797 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T191054 NZ_CP091626:3502440-3502685 [Salmonella enterica]
ATGAATGCCTCCGACGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT191054 WP_001296435.1 NZ_CP069589:2715998-2716333 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT191054 NZ_CP091626:c3502649-3502293 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGTCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References