Detailed information of TA system TA190996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 925069..925579
• Replicon: chromosome
• Accession: NZ_CP069582
• Organism: Staphylococcus carnosus strain FDAARGOS_1204

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6J34_RS04825
• Protein ID: WP_169929359.1
• Coordinates: 925069..925323 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: B9DKQ3
• Locus tag: I6J34_RS04830
• Protein ID: WP_012664283.1
• Coordinates: 925331..925579 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J34_RS04805	920114..921016	-	903	WP_046100210.1	ABC transporter substrate-binding protein	-
I6J34_RS04810	921148..922812	-	1665	WP_012664287.1	arginine--tRNA ligase	-
I6J34_RS04815	922814..923230	-	417	WP_103211859.1	DUF1934 family protein	-
I6J34_RS04820	923391..924581	-	1191	WP_046100212.1	amidohydrolase	-
I6J34_RS04825	925069..925323	-	255	WP_169929359.1	Txe/YoeB family addiction module toxin	Toxin
I6J34_RS04830	925331..925579	-	249	WP_012664283.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6J34_RS04835	925919..927330	-	1412	Protein_930	PLP-dependent aminotransferase family protein	-
I6J34_RS04840	927504..927873	+	370	Protein_931	fatty acid desaturase	-
I6J34_RS04845	928080..928697	+	618	WP_046100215.1	LysE family transporter	-
I6J34_RS04850	928881..929393	-	513	WP_012664280.1	YwhD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9914.30 Da
• Isoelectric Point: 9.8956

>T190996 WP_169929359.1 NZ_CP069582:c925323-925069 [Staphylococcus carnosus]
ISFSPEVFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESILAASCK
YHYQ

Nucleotide

• Length: 255 bp

>T190996 NZ_CP091611:213723-214208 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9305.30 Da
• Isoelectric Point: 4.2081

>AT190996 WP_012664283.1 NZ_CP069582:c925579-925331 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Nucleotide

• Length: 249 bp

>AT190996 NZ_CP091611:213448-213735 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATTAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A380F8S2