Detailed information of TA system TA190958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 1358235..1358824
• Replicon: chromosome
• Accession: NZ_CP069568
• Organism: Corynebacterium sp. FDAARGOS 1242 strain FDAARGOS_1242

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: I6J72_RS06450
• Protein ID: WP_082013920.1
• Coordinates: 1358543..1358824 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1F1GJT3
• Locus tag: I6J72_RS06445
• Protein ID: WP_070671880.1
• Coordinates: 1358235..1358534 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J72_RS06415	1353755..1354477	+	723	WP_204100366.1	hypothetical protein	-
I6J72_RS06420	1354477..1355013	+	537	WP_115021652.1	DUF402 domain-containing protein	-
I6J72_RS06425	1355058..1355978	+	921	WP_204100367.1	DUF808 domain-containing protein	-
I6J72_RS06430	1355982..1356779	-	798	WP_204100368.1	zinc transporter ZupT	-
I6J72_RS06435	1356904..1357722	+	819	WP_204100369.1	hypothetical protein	-
I6J72_RS06440	1357971..1358225	+	255	WP_204100370.1	hypothetical protein	-
I6J72_RS06445	1358235..1358534	-	300	WP_070671880.1	HigA family addiction module antidote protein	Antitoxin
I6J72_RS06450	1358543..1358824	-	282	WP_082013920.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6J72_RS06455	1359092..1360858	-	1767	WP_204100371.1	selenocysteine-specific translation elongation factor	-
I6J72_RS06460	1360859..1362145	-	1287	WP_204100372.1	L-seryl-tRNA(Sec) selenium transferase	-
I6J72_RS06470	1362297..1363271	+	975	WP_204100373.1	selenide, water dikinase SelD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (18-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (7-84)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10797.29 Da
• Isoelectric Point: 10.8344

>T190958 WP_082013920.1 NZ_CP069568:c1358824-1358543 [Corynebacterium sp. FDAARGOS 1242]
MIQSFANRDTELVWLRQASPRIDSRIHKTANRKLHQLDAAVSLQSLRVPPGNRLEALKGDRKGMYSIRVNQQWRITFRWT
EAGPADVAIEDYH

Nucleotide

• Length: 282 bp

>T190958 NZ_CP091594:5055802-5056020 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11086.73 Da
• Isoelectric Point: 5.1327

>AT190958 WP_070671880.1 NZ_CP069568:c1358534-1358235 [Corynebacterium sp. FDAARGOS 1242]
MSTKLYPPIHPGEVLNEDFIKAFGITQHKLAMAIGVPPRRINEIVHGKRGITADTALRLGRYFGVEPQFWVNLQGRYELE
LAEDSIAEEVSSIEPLEVA

Nucleotide

• Length: 300 bp

>AT190958 NZ_CP091594:5055401-5055775 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1F1GJT3