Detailed information of TA system TA190953

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1547136..1547318
• Replicon: chromosome
• Accession: NZ_CP069565
• Organism: Staphylococcus aureus strain FDAARGOS_1245

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: I6J75_RS07855
• Protein ID: WP_001801861.1
• Coordinates: 1547223..1547318 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1547136..1547195 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J75_RS07840	1546274..1546651	+	378	WP_001037045.1	DUF1433 domain-containing protein	-
I6J75_RS07845	1546845..1547021	+	177	Protein_1492	transposase	-
I6J75_RS07850	1546999..1547100	-	102	WP_001791893.1	hypothetical protein	-
-	1547136..1547195	+	60	-	-	Antitoxin
I6J75_RS07855	1547223..1547318	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
I6J75_RS07860	1547521..1547664	+	144	WP_001549059.1	transposase	-
I6J75_RS07865	1548268..1548651	+	384	WP_000070811.1	hypothetical protein	-
I6J75_RS07870	1548662..1548838	+	177	WP_000375476.1	hypothetical protein	-
I6J75_RS07875	1548840..1549025	+	186	WP_000809857.1	hypothetical protein	-
I6J75_RS07880	1549139..1549780	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
I6J75_RS07885	1549998..1550549	-	552	WP_000414205.1	hypothetical protein	-
I6J75_RS07890	1550647..1550991	-	345	WP_000627551.1	DUF3969 family protein	-
I6J75_RS07895	1551032..1551658	-	627	Protein_1502	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	1514047..1584758	70711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T190953 WP_001801861.1 NZ_CP069565:c1547318-1547223 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T190953 NZ_CP091594:1907305-1907715 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT190953 NZ_CP069565:1547136-1547195 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin