Detailed information of TA system TA190949

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1386030..1386368
• Replicon: chromosome
• Accession: NZ_CP069565
• Organism: Staphylococcus aureus strain FDAARGOS_1245

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: I6J75_RS06865
• Protein ID: WP_011447039.1
• Coordinates: 1386030..1386206 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1386194..1386368 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J75_RS06845	1381265..1385050	+	3786	WP_000582165.1	hypothetical protein	-
I6J75_RS06850	1385040..1385192	+	153	WP_001153681.1	hypothetical protein	-
I6J75_RS06855	1385239..1385526	+	288	WP_001040261.1	hypothetical protein	-
I6J75_RS06860	1385584..1385880	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
I6J75_RS06865	1386030..1386206	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1386194..1386368	-	175	-	-	Antitoxin
I6J75_RS06875	1386418..1386672	+	255	WP_000611512.1	phage holin	-
I6J75_RS06880	1386684..1387439	+	756	WP_000861038.1	CHAP domain-containing protein	-
I6J75_RS06885	1387630..1388121	+	492	WP_000919350.1	staphylokinase	-
I6J75_RS06890	1388771..1389106	+	336	Protein_1340	SH3 domain-containing protein	-
I6J75_RS06895	1389201..1389650	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
I6J75_RS06900	1390335..1390685	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
I6J75_RS06905	1390738..1390998	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn	1342812..1390685	47873

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T190949 WP_011447039.1 NZ_CP069565:1386030-1386206 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T190949 NZ_CP091594:c498956-498672 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT190949 NZ_CP069565:c1386368-1386194 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin