Detailed information of TA system TA190943

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1211457..1211720
• Replicon: chromosome
• Accession: NZ_CP069565
• Organism: Staphylococcus aureus strain FDAARGOS_1245

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: I6J75_RS05875
• Protein ID: WP_001802298.1
• Coordinates: 1211457..1211561 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1211556..1211720 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J75_RS05850	1206841..1207623	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
I6J75_RS05855	1207691..1208548	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
I6J75_RS05860	1209253..1209345	-	93	WP_001790138.1	hypothetical protein	-
I6J75_RS05865	1209634..1210770	+	1137	WP_000115564.1	SAP domain-containing protein	-
I6J75_RS05870	1210813..1211296	+	484	Protein_1141	recombinase family protein	-
I6J75_RS05875	1211457..1211561	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1211556..1211720	-	165	-	-	Antitoxin
I6J75_RS05880	1212061..1213152	-	1092	WP_000495671.1	lytic regulatory protein	-
I6J75_RS05885	1213418..1214398	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
I6J75_RS05890	1214400..1214720	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
I6J75_RS05895	1214872..1215537	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T190943 WP_001802298.1 NZ_CP069565:1211457-1211561 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T190943 NZ_CP091584:c97756-97274 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT190943 NZ_CP069565:c1211720-1211556 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin