Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 944892..945409 Replicon chromosome
Accession NZ_CP069565
Organism Staphylococcus aureus strain FDAARGOS_1245

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag I6J75_RS04490 Protein ID WP_000113262.1
Coordinates 945143..945409 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag I6J75_RS04485 Protein ID WP_000584502.1
Coordinates 944892..945143 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J75_RS04455 940593..941312 + 720 WP_000479576.1 amino acid ABC transporter permease -
I6J75_RS04460 941309..942040 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
I6J75_RS04465 942137..943387 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
I6J75_RS04470 943642..944001 + 360 WP_000819847.1 DUF4467 domain-containing protein -
I6J75_RS04475 944020..944619 + 600 WP_000162813.1 DsbA family protein -
I6J75_RS04480 944626..944727 + 102 WP_001791744.1 hypothetical protein -
I6J75_RS04485 944892..945143 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6J75_RS04490 945143..945409 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
I6J75_RS04495 945444..945515 + 72 Protein_875 hypothetical protein -
I6J75_RS04500 945704..947254 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
I6J75_RS04505 947440..947907 + 468 WP_000153344.1 SRPBCC domain-containing protein -
I6J75_RS04510 947991..948173 + 183 WP_000230294.1 hypothetical protein -
I6J75_RS04515 948390..949214 + 825 WP_000572040.1 formate/nitrite transporter family protein -
I6J75_RS04520 949447..949983 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T190942 WP_000113262.1 NZ_CP069565:945143-945409 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T190942 NZ_CP091583:188294-188764 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT190942 WP_000584502.1 NZ_CP069565:944892-945143 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT190942 NZ_CP091583:187854-188297 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCCAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References