Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 919877..920061 Replicon chromosome
Accession NZ_CP069565
Organism Staphylococcus aureus strain FDAARGOS_1245

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag I6J75_RS04355 Protein ID WP_000482650.1
Coordinates 919877..919984 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 920001..920061 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J75_RS04330 915239..915712 + 474 WP_000456489.1 GyrI-like domain-containing protein -
I6J75_RS04335 915835..917046 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
I6J75_RS04340 917228..917887 - 660 WP_000831298.1 membrane protein -
I6J75_RS04345 917947..919089 - 1143 WP_001176863.1 glycerate kinase -
I6J75_RS04350 919357..919743 + 387 WP_000779358.1 flippase GtxA -
I6J75_RS04355 919877..919984 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 920001..920061 - 61 - - Antitoxin
I6J75_RS04360 920612..922375 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
I6J75_RS04365 922400..924133 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
I6J75_RS04370 924364..924531 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T190940 WP_000482650.1 NZ_CP069565:919877-919984 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T190940 NZ_CP091582:3760349-3760451 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT190940 NZ_CP069565:c920061-920001 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References