Detailed information of TA system TA190920

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4536199..4536608
• Replicon: chromosome
• Accession: NZ_CP069559
• Organism: Escherichia coli strain FDAARGOS_1259

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0V9GCR5
• Locus tag: I6J89_RS21905
• Protein ID: WP_000132607.1
• Coordinates: 4536270..4536608 (+)
• Length: 113 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4536199..4536275 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J89_RS21895	4531387..4532697	+	1311	WP_001534837.1	restriction endonuclease subunit S	-
I6J89_RS21900	4532792..4536055	+	3264	WP_001534836.1	type I restriction endonuclease subunit R	-
-	4536199..4536275	-	77	NuclAT_12	-	Antitoxin
-	4536199..4536275	-	77	NuclAT_12	-	Antitoxin
-	4536199..4536275	-	77	NuclAT_12	-	Antitoxin
-	4536199..4536275	-	77	NuclAT_12	-	Antitoxin
-	4536199..4536275	-	77	NuclAT_13	-	Antitoxin
-	4536199..4536275	-	77	NuclAT_13	-	Antitoxin
-	4536199..4536275	-	77	NuclAT_13	-	Antitoxin
-	4536199..4536275	-	77	NuclAT_13	-	Antitoxin
I6J89_RS21905	4536270..4536608	+	339	WP_000132607.1	endoribonuclease SymE	Toxin
I6J89_RS21910	4536650..4536814	-	165	Protein_4271	DUF1127 domain-containing protein	-
I6J89_RS21915	4536992..4537162	+	171	WP_000199350.1	GntR family transcriptional regulator	-
I6J89_RS21920	4537292..4538212	-	921	WP_000181193.1	Rpn family recombination-promoting nuclease/putative transposase	-
I6J89_RS21925	4538397..4539677	+	1281	WP_001535800.1	DUF445 domain-containing protein	-
I6J89_RS21930	4539793..4540944	+	1152	WP_045233286.1	2-hydroxyacyl-CoA dehydratase subunit D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12283.01 Da
• Isoelectric Point: 7.8226

>T190920 WP_000132607.1 NZ_CP069559:4536270-4536608 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYNRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVISSKTPR

Nucleotide

• Length: 339 bp

>T190920 NZ_CP091571:c4770766-4770455 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Nucleotide

• Length: 77 bp

>AT190920 NZ_CP069559:c4536275-4536199 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0V9GCR5

Antitoxin