Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4459331..4459589 Replicon chromosome
Accession NZ_CP069559
Organism Escherichia coli strain FDAARGOS_1259

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I6J89_RS21520 Protein ID WP_000809168.1
Coordinates 4459437..4459589 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4459331..4459388 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J89_RS21505 4455160..4456419 - 1260 WP_000494928.1 hypothetical protein -
I6J89_RS21510 4456548..4458041 - 1494 WP_001468392.1 sulfatase-like hydrolase/transferase -
I6J89_RS21515 4458061..4458822 - 762 WP_001274832.1 hypothetical protein -
- 4459331..4459388 - 58 - - Antitoxin
I6J89_RS21520 4459437..4459589 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
I6J89_RS21525 4459694..4460824 - 1131 WP_001118464.1 molecular chaperone DnaJ -
I6J89_RS21530 4460913..4462829 - 1917 WP_000516135.1 molecular chaperone DnaK -
I6J89_RS21535 4463201..4463605 + 405 WP_000843687.1 DUF2541 family protein -
I6J89_RS21540 4463631..4464344 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T190917 WP_000809168.1 NZ_CP069559:4459437-4459589 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T190917 NZ_CP091571:c4146013-4145726 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 58 bp

>AT190917 NZ_CP069559:c4459388-4459331 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References