Detailed information of TA system TA190894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 1013054..1013705
• Replicon: chromosome
• Accession: NZ_CP069558
• Organism: Streptococcus constellatus strain FDAARGOS_1208

Toxin (Protein)

• Gene name: higB
• Uniprot ID: F9P6Y3
• Locus tag: I6J38_RS04950
• Protein ID: WP_006268450.1
• Coordinates: 1013340..1013705 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6J38_RS04945
• Protein ID: WP_020997975.1
• Coordinates: 1013054..1013350 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J38_RS04925	1008622..1009218	-	597	WP_006268506.1	recombination mediator RecR	-
I6J38_RS04930	1009229..1011289	-	2061	WP_020997973.1	penicillin-binding protein PBP2B	-
I6J38_RS04935	1011653..1011820	-	168	WP_006268192.1	hypothetical protein	-
I6J38_RS04940	1011827..1013032	-	1206	WP_020997974.1	hypothetical protein	-
I6J38_RS04945	1013054..1013350	-	297	WP_020997975.1	helix-turn-helix transcriptional regulator	Antitoxin
I6J38_RS04950	1013340..1013705	-	366	WP_006268450.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6J38_RS04955	1013771..1014046	-	276	WP_006268376.1	terminase small subunit	-
I6J38_RS04960	1014126..1014356	-	231	WP_022525741.1	hypothetical protein	-
I6J38_RS04965	1014595..1015005	-	411	WP_006268286.1	hypothetical protein	-
I6J38_RS04970	1014986..1015468	-	483	WP_006268241.1	hypothetical protein	-
I6J38_RS04975	1015487..1015867	-	381	WP_006268172.1	hypothetical protein	-
I6J38_RS04980	1015892..1016101	-	210	WP_006268092.1	hypothetical protein	-
I6J38_RS04985	1016181..1016357	-	177	WP_006267997.1	hypothetical protein	-
I6J38_RS04990	1016677..1017168	-	492	WP_006268458.1	hypothetical protein	-
I6J38_RS04995	1017487..1018341	-	855	WP_006268118.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1008622..1029844	21222

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14448.63 Da
• Isoelectric Point: 9.7920

>T190894 WP_006268450.1 NZ_CP069558:c1013705-1013340 [Streptococcus constellatus]
VHNIYFYKDKNGNEPILDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRTGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELADLKERGLDNEK

Nucleotide

• Length: 366 bp

>T190894 NZ_CP091569:871625-872038 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10755.42 Da
• Isoelectric Point: 4.8898

>AT190894 WP_020997975.1 NZ_CP069558:c1013350-1013054 [Streptococcus constellatus]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNERGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEGEQIS

Nucleotide

• Length: 297 bp

>AT190894 NZ_CP091569:871378-871644 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: F9P6Y3