Detailed information of TA system TA190891

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4430557..4430803
• Replicon: chromosome
• Accession: NZ_CP069549
• Organism: Escherichia coli strain FDAARGOS_1253

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: I6J83_RS21080
• Protein ID: WP_000956458.1
• Coordinates: 4430651..4430803 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	4430557..4430609 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J83_RS21065	4426067..4427866	+	1800	WP_000211918.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
I6J83_RS21070	4427866..4429578	+	1713	WP_001290708.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
I6J83_RS21075	4429652..4430386	+	735	WP_000039865.1	phosphoadenosine phosphosulfate reductase	-
-	4430557..4430609	-	53	-	-	Antitoxin
I6J83_RS21080	4430651..4430803	+	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
I6J83_RS21085	4430928..4431965	-	1038	WP_000490435.1	alkaline phosphatase isozyme conversion aminopeptidase	-
I6J83_RS21090	4432217..4433125	+	909	WP_000372392.1	sulfate adenylyltransferase subunit CysD	-
I6J83_RS21095	4433127..4434554	+	1428	WP_001090357.1	sulfate adenylyltransferase subunit CysN	-
I6J83_RS21100	4434554..4435159	+	606	WP_001173653.1	adenylyl-sulfate kinase	-
I6J83_RS21105	4435209..4435532	+	324	WP_001246113.1	DUF3561 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T190891 WP_000956458.1 NZ_CP069549:4430651-4430803 [Escherichia coli]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T190891 NZ_CP091569:206805-207290 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Nucleotide

• Length: 53 bp

>AT190891 NZ_CP069549:c4430609-4430557 [Escherichia coli]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin