Detailed information of TA system TA190887

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3560883..3561140
• Replicon: chromosome
• Accession: NZ_CP069549
• Organism: Escherichia coli strain FDAARGOS_1253

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: S1E8G5
• Locus tag: I6J83_RS16945
• Protein ID: WP_001135732.1
• Coordinates: 3560988..3561140 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3560883..3560931 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J83_RS16925	3556102..3557097	-	996	WP_001182669.1	O-acetyltransferase WecH	-
I6J83_RS16930	3557272..3557580	+	309	WP_000980157.1	YsaB family lipoprotein	-
I6J83_RS16935	3557675..3558586	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
I6J83_RS16940	3558596..3560665	+	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
-	3560883..3560931	-	49	-	-	Antitoxin
I6J83_RS16945	3560988..3561140	+	153	WP_001135732.1	type I toxin-antitoxin system toxin HokA	Toxin
I6J83_RS16950	3561328..3561540	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
I6J83_RS16955	3561821..3562111	-	291	WP_000455798.1	HTH-type transcriptional regulator	-
I6J83_RS16960	3562545..3563255	+	711	WP_000190516.1	DUF3053 domain-containing protein	-
I6J83_RS16965	3563305..3564279	-	975	WP_000805027.1	glyoxylate/hydroxypyruvate reductase GhrB	-
I6J83_RS16970	3564383..3565042	-	660	WP_000747625.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5998.28 Da
• Isoelectric Point: 7.7169

>T190887 WP_001135732.1 NZ_CP069549:3560988-3561140 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T190887 NZ_CP091566:c3689259-3688975 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT190887 NZ_CP069549:c3560931-3560883 [Escherichia coli]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: S1E8G5

Antitoxin