Detailed information of TA system TA190882

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2594285..2594543
• Replicon: chromosome
• Accession: NZ_CP069549
• Organism: Escherichia coli strain FDAARGOS_1253

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6J83_RS12490
• Protein ID: WP_000809168.1
• Coordinates: 2594391..2594543 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2594285..2594342 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J83_RS12475	2590113..2591372	-	1260	WP_000494924.1	hypothetical protein	-
I6J83_RS12480	2591501..2592994	-	1494	WP_001337669.1	sulfatase-like hydrolase/transferase	-
I6J83_RS12485	2593015..2593776	-	762	WP_001274832.1	hypothetical protein	-
-	2594285..2594342	-	58	-	-	Antitoxin
I6J83_RS12490	2594391..2594543	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
I6J83_RS12495	2594648..2595778	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6J83_RS12500	2595867..2597783	-	1917	WP_000516135.1	molecular chaperone DnaK	-
I6J83_RS12505	2598155..2598559	+	405	WP_000843689.1	DUF2541 family protein	-
I6J83_RS12510	2598585..2599298	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T190882 WP_000809168.1 NZ_CP069549:2594391-2594543 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T190882 NZ_CP091566:1798412-1798903 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT190882 NZ_CP069549:c2594342-2594285 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin