Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 56021..56624 Replicon plasmid unnamed3
Accession NZ_CP069540
Organism Acinetobacter pittii strain FDAARGOS_1214

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6J44_RS19415 Protein ID WP_000288004.1
Coordinates 56021..56350 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6J44_RS19420 Protein ID WP_001258993.1
Coordinates 56337..56624 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J44_RS19375 51823..52151 + 329 Protein_46 DUF4236 domain-containing protein -
I6J44_RS19380 52393..52905 - 513 WP_000464612.1 Fic family protein -
I6J44_RS19385 52908..53093 - 186 WP_000755724.1 hypothetical protein -
I6J44_RS19390 53260..54192 + 933 WP_000743263.1 IS5 family transposase -
I6J44_RS19395 54323..54520 - 198 WP_025464206.1 hypothetical protein -
I6J44_RS19400 54613..54831 - 219 WP_000994925.1 hypothetical protein -
I6J44_RS19405 54888..55490 - 603 WP_000096286.1 hypothetical protein -
I6J44_RS19410 55697..55966 + 270 WP_000453245.1 transcriptional regulator -
I6J44_RS19415 56021..56350 + 330 WP_000288004.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J44_RS19420 56337..56624 + 288 WP_001258993.1 helix-turn-helix domain-containing protein Antitoxin
I6J44_RS19425 56661..56849 - 189 WP_000340067.1 hypothetical protein -
I6J44_RS19430 57244..57567 - 324 Protein_57 DUF4236 domain-containing protein -
I6J44_RS19435 57576..57752 - 177 WP_002120129.1 hypothetical protein -
I6J44_RS19440 57824..58147 - 324 WP_005804845.1 hypothetical protein -
I6J44_RS19445 58502..59011 - 510 Protein_60 terminase -
I6J44_RS19450 58995..59518 - 524 Protein_61 DUF2280 domain-containing protein -
I6J44_RS19455 59609..60250 - 642 WP_000372120.1 hypothetical protein -
I6J44_RS19460 60219..60680 - 462 WP_000378528.1 hypothetical protein -
I6J44_RS19465 60741..61196 - 456 WP_001136766.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94387 94387
- flank IS/Tn - - 53260..54192 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12571.69 Da        Isoelectric Point: 8.8102

>T190839 WP_000288004.1 NZ_CP069540:56021-56350 [Acinetobacter pittii]
MYTIEYYSEDVQDEILTLPDGLLARYFNLTDRMVIYGANLGEPHTLPMSKGLFELRLKSQEGIARVMYCTLVGKRIVMLH
SFVKKTQKTPKQDLNLALDRMKEVKNANT

Download         Length: 330 bp

>T190839 NZ_CP091559:84381-85706 [Salmonella enterica]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGTTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10565.30 Da        Isoelectric Point: 10.1453

>AT190839 WP_001258993.1 NZ_CP069540:56337-56624 [Acinetobacter pittii]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTARRDAGLSQAQIAERMGTSVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV

Download         Length: 288 bp

>AT190839 NZ_CP091559:84083-84376 [Salmonella enterica]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References