Detailed information of TA system TA190838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 22571..23222
• Replicon: plasmid unnamed3
• Accession: NZ_CP069540
• Organism: Acinetobacter pittii strain FDAARGOS_1214

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6J44_RS19275
• Protein ID: WP_000269910.1
• Coordinates: 22571..22879 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6J44_RS19280
• Protein ID: WP_001140619.1
• Coordinates: 22920..23222 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J44_RS19245	18196..18714	+	519	WP_000447196.1	sel1 repeat family protein	-
I6J44_RS19250	18846..19358	+	513	WP_001089570.1	SMI1/KNR4 family protein	-
I6J44_RS19255	19566..20468	+	903	WP_000466974.1	hypothetical protein	-
I6J44_RS19260	20725..20970	+	246	WP_000246757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
I6J44_RS19265	20960..21253	+	294	WP_000221360.1	type II toxin-antitoxin system RelE/ParE family toxin	-
I6J44_RS19270	21440..21556	+	117	Protein_25	transposase	-
I6J44_RS19275	22571..22879	+	309	WP_000269910.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6J44_RS19280	22920..23222	+	303	WP_001140619.1	XRE family transcriptional regulator	Antitoxin
I6J44_RS19285	23215..23424	+	210	WP_000069470.1	hypothetical protein	-
I6J44_RS19290	23534..23761	-	228	WP_000555567.1	hypothetical protein	-
I6J44_RS19295	24527..24830	-	304	Protein_30	helix-turn-helix transcriptional regulator	-
I6J44_RS19300	24823..25179	-	357	WP_000269908.1	type II toxin-antitoxin system RelE/ParE family toxin	-
I6J44_RS19305	25737..26420	+	684	WP_000478902.1	hypothetical protein	-
I6J44_RS19310	26625..27153	+	529	Protein_33	IS3 family transposase	-
I6J44_RS19315	27396..27716	+	321	WP_001081101.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94387	94387

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-102)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-89)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11742.64 Da
• Isoelectric Point: 9.0002

>T190838 WP_000269910.1 NZ_CP069540:22571-22879 [Acinetobacter pittii]
MWTVITTDLFNEWLVQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIAD

Nucleotide

• Length: 309 bp

>T190838 NZ_CP091558:4975322-4975633 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11206.01 Da
• Isoelectric Point: 6.7282

>AT190838 WP_001140619.1 NZ_CP069540:22920-23222 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT190838 NZ_CP091558:4975634-4975924 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA