Detailed information of TA system TA190834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2766363..2766871
• Replicon: chromosome
• Accession: NZ_CP069534
• Organism: Corynebacterium glucuronolyticum strain FDAARGOS_1191

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: C2GL76
• Locus tag: I6J21_RS12450
• Protein ID: WP_005394567.1
• Coordinates: 2766614..2766871 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C2GL77
• Locus tag: I6J21_RS12445
• Protein ID: WP_005394569.1
• Coordinates: 2766363..2766617 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J21_RS12420	2761392..2762165	-	774	WP_005388136.1	HAD family hydrolase	-
I6J21_RS12425	2762162..2763418	-	1257	WP_005388135.1	serine--tRNA ligase	-
I6J21_RS12430	2763460..2764194	+	735	WP_005394574.1	GntR family transcriptional regulator	-
I6J21_RS12435	2764206..2765192	+	987	WP_005394571.1	septum formation family protein	-
I6J21_RS12440	2765189..2765536	+	348	WP_005388132.1	metallopeptidase family protein	-
I6J21_RS12445	2766363..2766617	+	255	WP_005394569.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I6J21_RS12450	2766614..2766871	+	258	WP_005394567.1	Txe/YoeB family addiction module toxin	Toxin
I6J21_RS12455	2767303..2768442	+	1140	WP_204098570.1	acyltransferase family protein	-
I6J21_RS12460	2768950..2769702	+	753	WP_005388125.1	type 1 glutamine amidotransferase domain-containing protein	-
I6J21_RS12465	2769682..2770857	-	1176	WP_005394564.1	LCP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	aph(3')-Ia	-	2741853..2767029	25176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10400.91 Da
• Isoelectric Point: 8.9245

>T190834 WP_005394567.1 NZ_CP069534:2766614-2766871 [Corynebacterium glucuronolyticum]
MKYIWSTHAWNDYLYWQETDRKTVKRINALIKDISRNGNDGIGKPEPLKYELSGYWLRRITDEHRLVYKYTDDALCLAMC
RYHWI

Nucleotide

• Length: 258 bp

>T190834 NZ_CP091558:c4412502-4412227 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.59 Da
• Isoelectric Point: 4.4621

>AT190834 WP_005394569.1 NZ_CP069534:2766363-2766617 [Corynebacterium glucuronolyticum]
MKTMSYSESRARYAEVLQSVVDNREEIVITRSGHESAVILSLDDYNSLRETAYLMRSPRNAQLLFEAVTELESGNGTARD
LLPE

Nucleotide

• Length: 255 bp

>AT190834 NZ_CP091558:c4412765-4412505 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Toxin

• AlphaFold DB: C2GL76

Antitoxin

• AlphaFold DB: C2GL77