Detailed information of TA system TA190820

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4524429..4524651
• Replicon: chromosome
• Accession: NZ_CP069528
• Organism: Escherichia coli strain FDAARGOS_1252

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: I6J82_RS21655
• Protein ID: WP_001295224.1
• Coordinates: 4524544..4524651 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4524429..4524495 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J82_RS21635	4519870..4520772	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
I6J82_RS21640	4520783..4521766	+	984	WP_001540025.1	dipeptide ABC transporter ATP-binding protein	-
I6J82_RS21645	4521763..4522767	+	1005	WP_000103577.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6J82_RS21650	4522797..4524068	-	1272	WP_001298005.1	amino acid permease	-
-	4524429..4524495	-	67	-	-	Antitoxin
I6J82_RS21655	4524544..4524651	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
I6J82_RS21660	4524738..4526417	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
I6J82_RS21665	4526414..4526605	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
I6J82_RS21670	4526602..4528173	-	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
I6J82_RS21675	4528446..4528634	+	189	WP_001063314.1	YhjR family protein	-
I6J82_RS21680	4528646..4529398	+	753	WP_000279525.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T190820 WP_001295224.1 NZ_CP069528:4524544-4524651 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T190820 NZ_CP091556:c4352050-4351559 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT190820 NZ_CP069528:c4524495-4524429 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin