Detailed information of TA system TA190812

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 3437714..3438126
• Replicon: chromosome
• Accession: NZ_CP069528
• Organism: Escherichia coli strain FDAARGOS_1252

Toxin (Protein)

• Gene name: symE
• Uniprot ID: S1NWQ7
• Locus tag: I6J82_RS16505
• Protein ID: WP_000132614.1
• Coordinates: 3437785..3438126 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	3437714..3437790 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J82_RS16495	3434326..3435795	+	1470	WP_001387312.1	type I restriction-modification system subunit M	-
I6J82_RS16500	3435795..3437564	+	1770	WP_001513535.1	restriction endonuclease subunit S	-
-	3437714..3437790	-	77	NuclAT_5	-	Antitoxin
-	3437714..3437790	-	77	NuclAT_5	-	Antitoxin
-	3437714..3437790	-	77	NuclAT_5	-	Antitoxin
-	3437714..3437790	-	77	NuclAT_5	-	Antitoxin
-	3437714..3437790	-	77	NuclAT_6	-	Antitoxin
-	3437714..3437790	-	77	NuclAT_6	-	Antitoxin
-	3437714..3437790	-	77	NuclAT_6	-	Antitoxin
-	3437714..3437790	-	77	NuclAT_6	-	Antitoxin
I6J82_RS16505	3437785..3438126	+	342	WP_000132614.1	endoribonuclease SymE	Toxin
I6J82_RS16510	3438173..3440329	-	2157	WP_001513533.1	DUF262 domain-containing protein	-
I6J82_RS16515	3440364..3440444	-	81	WP_020233658.1	hypothetical protein	-
I6J82_RS16520	3440672..3441592	-	921	WP_001513532.1	Rpn family recombination-promoting nuclease/putative transposase	-
I6J82_RS16525	3441777..3443057	+	1281	WP_001338077.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	cheD	3422102..3438126	16024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12266.07 Da
• Isoelectric Point: 8.4982

>T190812 WP_000132614.1 NZ_CP069528:3437785-3438126 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T190812 NZ_CP091556:884520-884918 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT190812 NZ_CP069528:c3437790-3437714 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: S1NWQ7

Antitoxin