Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3358023..3358281 Replicon chromosome
Accession NZ_CP069528
Organism Escherichia coli strain FDAARGOS_1252

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I6J82_RS16110 Protein ID WP_000809168.1
Coordinates 3358129..3358281 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3358023..3358080 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J82_RS16095 3353852..3355111 - 1260 WP_000494929.1 hypothetical protein -
I6J82_RS16100 3355240..3356733 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
I6J82_RS16105 3356753..3357514 - 762 WP_001274832.1 hypothetical protein -
- 3358023..3358080 - 58 - - Antitoxin
I6J82_RS16110 3358129..3358281 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
I6J82_RS16115 3358386..3359516 - 1131 WP_001118464.1 molecular chaperone DnaJ -
I6J82_RS16120 3359605..3361521 - 1917 WP_000516135.1 molecular chaperone DnaK -
I6J82_RS16125 3361892..3362296 + 405 WP_000843687.1 DUF2541 family protein -
I6J82_RS16130 3362322..3363035 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T190810 WP_000809168.1 NZ_CP069528:3358129-3358281 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T190810 NZ_CP091556:366397-366672 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 58 bp

>AT190810 NZ_CP069528:c3358080-3358023 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References