Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1703520..1704082 Replicon chromosome
Accession NZ_CP069528
Organism Escherichia coli strain FDAARGOS_1252

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag I6J82_RS07935 Protein ID WP_000605675.1
Coordinates 1703804..1704082 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8D9UMF3
Locus tag I6J82_RS07930 Protein ID WP_021528209.1
Coordinates 1703520..1703804 (-) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J82_RS07915 1698701..1701748 + 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -
I6J82_RS07920 1701761..1702645 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
I6J82_RS07925 1702638..1703291 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
I6J82_RS07930 1703520..1703804 - 285 WP_021528209.1 HigA family addiction module antidote protein Antitoxin
I6J82_RS07935 1703804..1704082 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J82_RS07940 1704268..1705278 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
I6J82_RS07945 1705412..1707109 - 1698 WP_000433460.1 malate dehydrogenase -
I6J82_RS07950 1707266..1707403 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
I6J82_RS07955 1707505..1707720 - 216 WP_000495766.1 biofilm-dependent modulation protein -
I6J82_RS07960 1708065..1708496 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-92)

Antitoxin

(14-65)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T190796 WP_000605675.1 NZ_CP069528:c1704082-1703804 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T190796 NZ_CP091554:c1163428-1163210 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.14 Da        Isoelectric Point: 8.8567

>AT190796 WP_021528209.1 NZ_CP069528:c1703804-1703520 [Escherichia coli]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT190796 NZ_CP091554:c1163830-1163456 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1Q1V8


Antitoxin

Source ID Structure

References