Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 541591..542390 Replicon chromosome
Accession NZ_CP069522
Organism Escherichia coli strain FDAARGOS_1267

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag I6J97_RS02740 Protein ID WP_000347251.1
Coordinates 541591..542055 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag I6J97_RS02745 Protein ID WP_001296435.1
Coordinates 542055..542390 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J97_RS02710 536592..537026 - 435 WP_000948834.1 PTS sugar transporter subunit IIA -
I6J97_RS02715 537044..537922 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
I6J97_RS02720 537912..538691 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
I6J97_RS02725 538702..539175 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
I6J97_RS02730 539198..540478 - 1281 WP_000681930.1 tagatose-bisphosphate aldolase subunit KbaZ -
I6J97_RS02735 540727..541536 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
I6J97_RS02740 541591..542055 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
I6J97_RS02745 542055..542390 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
I6J97_RS02750 542539..544110 - 1572 WP_001273939.1 galactarate dehydratase -
I6J97_RS02755 544485..545819 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
I6J97_RS02760 545835..546605 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T190761 WP_000347251.1 NZ_CP069522:c542055-541591 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T190761 NZ_CP091544:317502-317870 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT190761 WP_001296435.1 NZ_CP069522:c542390-542055 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT190761 NZ_CP091544:317284-317505 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References