190734

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1110979..1111541 Replicon chromosome
Accession NZ_CP069517
Organism Escherichia coli strain FDAARGOS_1262

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag I6J92_RS05410 Protein ID WP_000605675.1
Coordinates 1111263..1111541 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag I6J92_RS05405 Protein ID WP_000781370.1
Coordinates 1110979..1111263 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J92_RS05390 1106160..1109207 + 3048 WP_077634457.1 formate dehydrogenase-N subunit alpha -
I6J92_RS05395 1109220..1110104 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
I6J92_RS05400 1110097..1110750 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
I6J92_RS05405 1110979..1111263 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
I6J92_RS05410 1111263..1111541 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J92_RS05415 1111727..1112737 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
I6J92_RS05420 1112870..1114567 - 1698 WP_000433462.1 malate dehydrogenase -
I6J92_RS05425 1114723..1114860 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
I6J92_RS05430 1114962..1115177 - 216 WP_000495766.1 biofilm-dependent modulation protein -
I6J92_RS05435 1115522..1115953 + 432 WP_021580110.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T190734 WP_000605675.1 NZ_CP069517:c1111541-1111263 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T190734 NZ_CP091540:3536673-3536891 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT190734 WP_000781370.1 NZ_CP069517:c1111263-1110979 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT190734 NZ_CP091540:3536271-3536645 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References