Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3815849..3816107 Replicon chromosome
Accession NZ_CP069500
Organism Escherichia coli strain FDAARGOS_1258

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I6J88_RS18705 Protein ID WP_000809168.1
Coordinates 3815849..3816001 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3816050..3816107 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J88_RS18685 3811093..3811806 - 714 WP_001102393.1 acidic protein MsyB -
I6J88_RS18690 3811832..3812236 - 405 WP_000843687.1 DUF2541 family protein -
I6J88_RS18695 3812609..3814525 + 1917 WP_000516135.1 molecular chaperone DnaK -
I6J88_RS18700 3814614..3815744 + 1131 WP_001118464.1 molecular chaperone DnaJ -
I6J88_RS18705 3815849..3816001 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3816050..3816107 + 58 - - Antitoxin
I6J88_RS18710 3816616..3817377 + 762 WP_001274832.1 hypothetical protein -
I6J88_RS18715 3817397..3818890 + 1494 WP_001468392.1 sulfatase-like hydrolase/transferase -
I6J88_RS18720 3819019..3820278 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T190684 WP_000809168.1 NZ_CP069500:c3816001-3815849 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T190684 NZ_CP091525:c173434-173339 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT190684 NZ_CP069500:3816050-3816107 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References