Detailed information of TA system TA190597

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2765785..2766007
• Replicon: chromosome
• Accession: NZ_CP069480
• Organism: Escherichia coli strain FDAARGOS_1257

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: I6J87_RS13335
• Protein ID: WP_001295224.1
• Coordinates: 2765900..2766007 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2765785..2765851 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J87_RS13315	2761226..2762128	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
I6J87_RS13320	2762139..2763122	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
I6J87_RS13325	2763119..2764123	+	1005	WP_000103577.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6J87_RS13330	2764153..2765424	-	1272	WP_001298005.1	amino acid permease	-
-	2765785..2765851	-	67	-	-	Antitoxin
I6J87_RS13335	2765900..2766007	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
I6J87_RS13340	2766094..2767773	-	1680	WP_000191565.1	cellulose biosynthesis protein BcsG	-
I6J87_RS13345	2767770..2767961	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
I6J87_RS13350	2767958..2769530	-	1573	Protein_2600	cellulose biosynthesis protein BcsE	-
I6J87_RS13355	2769803..2769991	+	189	WP_001063314.1	YhjR family protein	-
I6J87_RS13360	2770003..2770755	+	753	WP_000279536.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T190597 WP_001295224.1 NZ_CP069480:2765900-2766007 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T190597 NZ_CP091481:c4069309-4068968 [Enterobacter cloacae complex sp. ECL414]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTAGCACCCGTGGCTGTCTGGCAAATGCTACTGAC
CCGCCTGCTGAAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGAATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT190597 NZ_CP069480:c2765851-2765785 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin