Detailed information of TA system TA190587

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1569973..1570231
• Replicon: chromosome
• Accession: NZ_CP069480
• Organism: Escherichia coli strain FDAARGOS_1257

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6J87_RS07575
• Protein ID: WP_000809168.1
• Coordinates: 1570079..1570231 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1569973..1570030 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J87_RS07560	1565802..1567061	-	1260	WP_000494927.1	hypothetical protein	-
I6J87_RS07565	1567190..1568683	-	1494	WP_001314416.1	sulfatase-like hydrolase/transferase	-
I6J87_RS07570	1568703..1569464	-	762	WP_001274828.1	hypothetical protein	-
-	1569973..1570030	-	58	-	-	Antitoxin
I6J87_RS07575	1570079..1570231	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
I6J87_RS07580	1570336..1571466	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6J87_RS07585	1571555..1573471	-	1917	WP_001540853.1	molecular chaperone DnaK	-
I6J87_RS07590	1573843..1574247	+	405	WP_000843689.1	DUF2541 family protein	-
I6J87_RS07595	1574273..1574986	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T190587 WP_000809168.1 NZ_CP069480:1570079-1570231 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T190587 NZ_CP091476:233431-233781 [Bacillus cereus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT190587 NZ_CP069480:c1570030-1569973 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin