Detailed information of TA system TA190571

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 806709..807047
• Replicon: chromosome
• Accession: NZ_CP069470
• Organism: Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: I6J76_RS04130
• Protein ID: WP_011447039.1
• Coordinates: 806709..806885 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	806873..807047 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J76_RS04110	801944..805729	+	3786	WP_000582165.1	hypothetical protein	-
I6J76_RS04115	805719..805871	+	153	WP_001153681.1	hypothetical protein	-
I6J76_RS04120	805918..806205	+	288	WP_001040261.1	hypothetical protein	-
I6J76_RS04125	806263..806559	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
I6J76_RS04130	806709..806885	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	806873..807047	-	175	-	-	Antitoxin
I6J76_RS04140	807097..807351	+	255	WP_000611512.1	phage holin	-
I6J76_RS04145	807363..808118	+	756	WP_000861038.1	CHAP domain-containing protein	-
I6J76_RS04150	808309..808800	+	492	WP_000919350.1	staphylokinase	-
I6J76_RS04155	809450..809785	+	336	Protein_816	SH3 domain-containing protein	-
I6J76_RS04160	809880..810329	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
I6J76_RS04165	811014..811364	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
I6J76_RS04170	811417..811677	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	755428..811364	55936

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T190571 WP_011447039.1 NZ_CP069470:806709-806885 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T190571 NZ_CP091456:c2235986-2235708 [Avibacterium sp. 20-132]
ATGATTACCCATTTTTCCTGTAAAGAAACCCAGGCATTTTTTGAAGGTAAACGAATACGGCGTTTTATCGCATTTGAAAA
AGTCGCAACGCGAAAACTTCAACAACTCAATGCAGCAACAGAGCTTAACTTTTTAAAAATTCCTCCGGGAAATCATTTAG
AACAGCTTTCTGGTGATCGAAAAGGGCAATACAGCATTCGAATTAACGATCAGTGGCGGATTTGTTTTACTTGGTTAAAT
GGACACGCCACTGATGTTGAAATTGTGGATTACCACTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT190571 NZ_CP069470:c807047-806873 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin