Detailed information of TA system TA190566

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 632136..632415
• Replicon: chromosome
• Accession: NZ_CP069470
• Organism: Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: I6J76_RS03140
• Protein ID: WP_001802298.1
• Coordinates: 632136..632240 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	632236..632415 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J76_RS03115	627520..628302	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
I6J76_RS03120	628370..629227	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
I6J76_RS03125	629932..630024	-	93	WP_001790138.1	hypothetical protein	-
I6J76_RS03130	630313..631449	+	1137	WP_000115564.1	SAP domain-containing protein	-
I6J76_RS03135	631492..631975	+	484	Protein_617	recombinase family protein	-
I6J76_RS03140	632136..632240	+	105	WP_001802298.1	hypothetical protein	Toxin
-	632236..632415	-	180	-	-	Antitoxin
I6J76_RS03145	632740..633831	-	1092	WP_000495671.1	lytic regulatory protein	-
I6J76_RS03150	634097..635077	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
I6J76_RS03155	635079..635399	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
I6J76_RS03160	635551..636216	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T190566 WP_001802298.1 NZ_CP069470:632136-632240 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T190566 NZ_CP091456:1382475-1382780 [Avibacterium sp. 20-132]
GTGTTTAATTTAACGGCTAAGCATTTTAAAGACGATTATCTTTATCGTTTTTTTCAGTATGGAGAATTGCATAGCAAAAT
TCCTGCAAATTTAGCAAAAGTATTAGCGAGAAAATTAGATATGATAAATGCAGCAGAAAATTTGAATGATTTACGCGTTC
CGCCTGCAAATCGTCTTGAGTTACTAGAGCCTAAAGAAAATAAACGCTATTCTATTCGGGTTAATAAACAATATCGTCTG
ATTTTTCATTTTGATAATGGCGAACTTTCTCAGCTTTATCTTGATCCTCATCGTTATGATTTATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT190566 NZ_CP069470:c632415-632236 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin