190564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 365571..366088 Replicon chromosome
Accession NZ_CP069470
Organism Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag I6J76_RS01755 Protein ID WP_000113262.1
Coordinates 365822..366088 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag I6J76_RS01750 Protein ID WP_000584502.1
Coordinates 365571..365822 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J76_RS01720 361272..361991 + 720 WP_000479576.1 amino acid ABC transporter permease -
I6J76_RS01725 361988..362719 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
I6J76_RS01730 362816..364066 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
I6J76_RS01735 364321..364680 + 360 WP_000819847.1 DUF4467 domain-containing protein -
I6J76_RS01740 364699..365298 + 600 WP_000162813.1 DsbA family protein -
I6J76_RS01745 365305..365406 + 102 WP_001791744.1 hypothetical protein -
I6J76_RS01750 365571..365822 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6J76_RS01755 365822..366088 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
I6J76_RS01760 366123..366194 + 72 Protein_351 hypothetical protein -
I6J76_RS01765 366383..367933 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
I6J76_RS01770 368119..368586 + 468 WP_000153344.1 SRPBCC domain-containing protein -
I6J76_RS01775 368670..368852 + 183 WP_000230294.1 hypothetical protein -
I6J76_RS01780 369069..369893 + 825 WP_000572040.1 formate/nitrite transporter family protein -
I6J76_RS01785 370126..370662 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T190564 WP_000113262.1 NZ_CP069470:365822-366088 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T190564 NZ_CP091456:500048-500338 [Avibacterium sp. 20-132]
ATGACCTATAAACTGCTTTTCGATAAACGGGCATTAAAGGAATGGCAAAAATTAGGCGACACCTTACGCCAGCAATTCAA
AGCAAAACTTATTGAACGGTTAGAAAACCCTCACGTTCCAAGTGATAAATTGCACGGTTATCAAACACTCTATAAAATCA
AATTGCGATCAGCAGGCTATCGGCTTGTTTATGATGTAAATGACAATAAAATTACGGTGATCGTGCTTTCAGTTGGCAAA
AGAAATCGACTAGAAGCCTATAAAAAAGCCCTATTAAGAAAAACCCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT190564 WP_000584502.1 NZ_CP069470:365571-365822 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT190564 NZ_CP091456:499798-500058 [Avibacterium sp. 20-132]
ATGGCAATTCATCAAATCTTAACCCGCCACACCGCAAGCATTAGCGACTTGAAAAAAAATCCAATGGGGATCGTATCAGA
AGGTACAGTAGAAGAAGGTGCAATCGCTATTCTAAACCGTAATGAACCCGTTTTTTACTGTATCAATCCCGCACTGTTTG
CTGCTATCCAAGAAATGCTAGAAGATAAAGAATTAGGCGAAATTGCCACAAAACGTCTTGCCACTCTTGACCCTGTAGAG
GTTAGCCTAGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References