Detailed information of TA system TA190562

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 340556..340740
• Replicon: chromosome
• Accession: NZ_CP069470
• Organism: Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: I6J76_RS01620
• Protein ID: WP_000482650.1
• Coordinates: 340556..340663 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	340680..340740 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J76_RS01595	335918..336391	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
I6J76_RS01600	336514..337725	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
I6J76_RS01605	337907..338566	-	660	WP_000831298.1	membrane protein	-
I6J76_RS01610	338626..339768	-	1143	WP_001176863.1	glycerate kinase	-
I6J76_RS01615	340036..340422	+	387	WP_000779358.1	flippase GtxA	-
I6J76_RS01620	340556..340663	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	340680..340740	-	61	-	-	Antitoxin
I6J76_RS01625	341291..343054	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
I6J76_RS01630	343079..344812	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
I6J76_RS01635	345043..345210	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T190562 WP_000482650.1 NZ_CP069470:340556-340663 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T190562 NZ_CP091453:2762-3049 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT190562 NZ_CP069470:c340740-340680 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin