Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 308717..309240 Replicon chromosome
Accession NZ_CP069470
Organism Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag I6J76_RS01480 Protein ID WP_000074048.1
Coordinates 308974..309240 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag I6J76_RS01475 Protein ID WP_000587616.1
Coordinates 308717..308974 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J76_RS01450 303797..304990 + 1194 WP_000675401.1 MFS transporter -
I6J76_RS01455 305214..305963 - 750 WP_000072444.1 hypothetical protein -
I6J76_RS01460 306158..307735 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
I6J76_RS01465 307903..308358 - 456 WP_000732082.1 DUF1307 domain-containing protein -
I6J76_RS01470 308417..308611 + 195 WP_001790145.1 hypothetical protein -
I6J76_RS01475 308717..308974 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6J76_RS01480 308974..309240 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
I6J76_RS01485 309595..310671 + 1077 WP_001076671.1 M42 family metallopeptidase -
I6J76_RS01490 310919..311581 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
I6J76_RS01495 311574..312350 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
I6J76_RS01500 312746..313933 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T190561 WP_000074048.1 NZ_CP069470:308974-309240 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T190561 NZ_CP091452:c3480037-3479648 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT190561 WP_000587616.1 NZ_CP069470:308717-308974 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT190561 NZ_CP091452:c3480301-3480044 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References