Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 37127..37553 | Replicon | plasmid unnamed2 |
Accession | NZ_CP069461 | ||
Organism | Escherichia coli strain FDAARGOS_1249 |
Toxin (Protein)
Gene name | hok | Uniprot ID | P11895 |
Locus tag | I6J79_RS24825 | Protein ID | WP_001312861.1 |
Coordinates | 37395..37553 (+) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 37127..37351 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6J79_RS24790 | 32182..32410 | + | 229 | Protein_42 | hypothetical protein | - |
I6J79_RS24795 | 33053..33592 | + | 540 | WP_001530505.1 | single-stranded DNA-binding protein | - |
I6J79_RS24800 | 33654..33887 | + | 234 | WP_000006030.1 | DUF905 family protein | - |
I6J79_RS24805 | 33952..35910 | + | 1959 | WP_204147837.1 | ParB/RepB/Spo0J family partition protein | - |
I6J79_RS24810 | 35965..36399 | + | 435 | WP_204147838.1 | conjugation system SOS inhibitor PsiB | - |
I6J79_RS24815 | 36396..37115 | + | 720 | WP_001276234.1 | plasmid SOS inhibition protein A | - |
I6J79_RS24820 | 37127..37315 | - | 189 | WP_001336239.1 | hypothetical protein | - |
- | 37127..37351 | + | 225 | NuclAT_0 | - | Antitoxin |
- | 37127..37351 | + | 225 | NuclAT_0 | - | Antitoxin |
- | 37127..37351 | + | 225 | NuclAT_0 | - | Antitoxin |
- | 37127..37351 | + | 225 | NuclAT_0 | - | Antitoxin |
I6J79_RS24825 | 37395..37553 | + | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
I6J79_RS24830 | 38001..38198 | - | 198 | Protein_50 | hypothetical protein | - |
I6J79_RS24835 | 38200..38487 | + | 288 | WP_000107535.1 | hypothetical protein | - |
I6J79_RS24840 | 38608..38943 | + | 336 | Protein_52 | DUF932 domain-containing protein | - |
I6J79_RS24845 | 38987..39211 | - | 225 | Protein_53 | transposase | - |
I6J79_RS24850 | 39270..40238 | - | 969 | WP_073970534.1 | IS5 family transposase | - |
I6J79_RS24855 | 40269..41266 | - | 998 | Protein_55 | IS3 family transposase | - |
I6J79_RS24860 | 41321..42055 | + | 735 | Protein_56 | conjugal transfer protein TraN | - |
I6J79_RS24865 | 42082..42339 | + | 258 | WP_000864309.1 | conjugal transfer protein TrbE | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | senB | 1..114299 | 114299 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 6082.32 Da Isoelectric Point: 9.2584
>T190554 WP_001312861.1 NZ_CP069461:37395-37553 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 159 bp
>T190554 NZ_CP091428:123172-123588 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 225 bp
>AT190554 NZ_CP069461:37127-37351 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGTCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGTCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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