Detailed information of TA system TA190501

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2342193..2342451
• Replicon: chromosome
• Accession: NZ_CP069453
• Organism: Escherichia coli strain FDAARGOS_1254

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6J84_RS10940
• Protein ID: WP_000809168.1
• Coordinates: 2342193..2342345 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2342394..2342451 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J84_RS10920	2337438..2338151	-	714	WP_001102393.1	acidic protein MsyB	-
I6J84_RS10925	2338177..2338581	-	405	WP_000843689.1	DUF2541 family protein	-
I6J84_RS10930	2338953..2340869	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6J84_RS10935	2340958..2342088	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6J84_RS10940	2342193..2342345	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	2342394..2342451	+	58	-	-	Antitoxin
I6J84_RS10945	2342960..2343721	+	762	WP_001274832.1	hypothetical protein	-
I6J84_RS10950	2343742..2345235	+	1494	WP_001337669.1	sulfatase-like hydrolase/transferase	-
I6J84_RS10955	2345364..2346623	+	1260	WP_000494924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T190501 WP_000809168.1 NZ_CP069453:c2342345-2342193 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T190501 NZ_CP091378:1367592-1367981 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT190501 NZ_CP069453:2342394-2342451 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin