Detailed information of TA system TA190496

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1373528..1373785
• Replicon: chromosome
• Accession: NZ_CP069453
• Organism: Escherichia coli strain FDAARGOS_1254

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: S1E8G5
• Locus tag: I6J84_RS06470
• Protein ID: WP_001135732.1
• Coordinates: 1373528..1373680 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	1373737..1373785 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J84_RS06445	1369626..1370285	+	660	WP_000747625.1	OmpA family lipoprotein	-
I6J84_RS06450	1370389..1371363	+	975	WP_000805027.1	glyoxylate/hydroxypyruvate reductase GhrB	-
I6J84_RS06455	1371413..1372123	-	711	WP_000190516.1	DUF3053 domain-containing protein	-
I6J84_RS06460	1372557..1372847	+	291	WP_000455798.1	HTH-type transcriptional regulator	-
I6J84_RS06465	1373128..1373340	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
I6J84_RS06470	1373528..1373680	-	153	WP_001135732.1	type I toxin-antitoxin system toxin HokA	Toxin
-	1373737..1373785	+	49	-	-	Antitoxin
I6J84_RS06475	1374003..1376072	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
I6J84_RS06480	1376082..1376993	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
I6J84_RS06485	1377088..1377396	-	309	WP_000980157.1	YsaB family lipoprotein	-
I6J84_RS06490	1377571..1378566	+	996	WP_001182669.1	O-acetyltransferase WecH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5998.28 Da
• Isoelectric Point: 7.7169

>T190496 WP_001135732.1 NZ_CP069453:c1373680-1373528 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T190496 NZ_CP091374:3915626-3916015 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT190496 NZ_CP069453:1373737-1373785 [Escherichia coli]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: S1E8G5

Antitoxin