Detailed information of TA system TA190492

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 503825..504071
• Replicon: chromosome
• Accession: NZ_CP069453
• Organism: Escherichia coli strain FDAARGOS_1254

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: I6J84_RS02340
• Protein ID: WP_000956458.1
• Coordinates: 503825..503977 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	504019..504071 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J84_RS02315	499096..499419	-	324	WP_001246113.1	DUF3561 family protein	-
I6J84_RS02320	499469..500074	-	606	WP_204086915.1	adenylyl-sulfate kinase	-
I6J84_RS02325	500074..501501	-	1428	WP_001090357.1	sulfate adenylyltransferase subunit CysN	-
I6J84_RS02330	501503..502411	-	909	WP_000372392.1	sulfate adenylyltransferase subunit CysD	-
I6J84_RS02335	502663..503700	+	1038	WP_000490435.1	alkaline phosphatase isozyme conversion aminopeptidase	-
I6J84_RS02340	503825..503977	-	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	504019..504071	+	53	-	-	Antitoxin
I6J84_RS02345	504242..504976	-	735	WP_000039865.1	phosphoadenosine phosphosulfate reductase	-
I6J84_RS02350	505050..506762	-	1713	WP_001290708.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
I6J84_RS02355	506762..508561	-	1800	WP_000211918.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T190492 WP_000956458.1 NZ_CP069453:c503977-503825 [Escherichia coli]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T190492 NZ_CP091371:c3289824-3289435 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 53 bp

>AT190492 NZ_CP069453:504019-504071 [Escherichia coli]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin