Detailed information of TA system TA190489

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4956923..4957145
• Replicon: chromosome
• Accession: NZ_CP069451
• Organism: Escherichia coli strain FDAARGOS_1256

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: I6J86_RS23535
• Protein ID: WP_001295224.1
• Coordinates: 4956923..4957030 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4957079..4957145 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J86_RS23510	4952176..4952928	-	753	WP_000279536.1	cellulose biosynthesis protein BcsQ	-
I6J86_RS23515	4952940..4953128	-	189	WP_001063314.1	YhjR family protein	-
I6J86_RS23520	4953401..4954972	+	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
I6J86_RS23525	4954969..4955160	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
I6J86_RS23530	4955157..4956836	+	1680	WP_000191565.1	cellulose biosynthesis protein BcsG	-
I6J86_RS23535	4956923..4957030	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4957079..4957145	+	67	-	-	Antitoxin
I6J86_RS23540	4957506..4958777	+	1272	WP_001298005.1	amino acid permease	-
I6J86_RS23545	4958807..4959811	-	1005	WP_000103577.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6J86_RS23550	4959808..4960791	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
I6J86_RS23555	4960802..4961704	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T190489 WP_001295224.1 NZ_CP069451:c4957030-4956923 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T190489 NZ_CP091370:156229-156618 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT190489 NZ_CP069451:4957079-4957145 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin