Detailed information of TA system TA190466

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1032838..1033096
• Replicon: chromosome
• Accession: NZ_CP069451
• Organism: Escherichia coli strain FDAARGOS_1256

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6J86_RS04890
• Protein ID: WP_000809168.1
• Coordinates: 1032838..1032990 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1033039..1033096 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J86_RS04870	1028083..1028796	-	714	WP_001102393.1	acidic protein MsyB	-
I6J86_RS04875	1028822..1029226	-	405	WP_000843689.1	DUF2541 family protein	-
I6J86_RS04880	1029598..1031514	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6J86_RS04885	1031603..1032733	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6J86_RS04890	1032838..1032990	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	1033039..1033096	+	58	-	-	Antitoxin
I6J86_RS04895	1033605..1034366	+	762	WP_001274828.1	hypothetical protein	-
I6J86_RS04900	1034386..1035879	+	1494	WP_001314416.1	sulfatase-like hydrolase/transferase	-
I6J86_RS04905	1036008..1037267	+	1260	WP_000494927.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T190466 WP_000809168.1 NZ_CP069451:c1032990-1032838 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T190466 NZ_CP091360:790125-790514 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT190466 NZ_CP069451:1033039-1033096 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin