Detailed information of TA system TA190452

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4429198..4429456
• Replicon: chromosome
• Accession: NZ_CP069447
• Organism: Escherichia coli strain FDAARGOS_1255

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6J85_RS21060
• Protein ID: WP_000809168.1
• Coordinates: 4429304..4429456 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4429198..4429255 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J85_RS21045	4425027..4426286	-	1260	WP_000494928.1	hypothetical protein	-
I6J85_RS21050	4426415..4427908	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
I6J85_RS21055	4427928..4428689	-	762	WP_001274832.1	hypothetical protein	-
-	4429198..4429255	-	58	-	-	Antitoxin
I6J85_RS21060	4429304..4429456	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
I6J85_RS21065	4429561..4430691	-	1131	WP_001118465.1	molecular chaperone DnaJ	-
I6J85_RS21070	4430780..4432696	-	1917	WP_000516135.1	molecular chaperone DnaK	-
I6J85_RS21075	4433068..4433472	+	405	WP_000843687.1	DUF2541 family protein	-
I6J85_RS21080	4433498..4434211	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T190452 WP_000809168.1 NZ_CP069447:4429304-4429456 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T190452 NZ_CP091353:c3048082-3047693 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT190452 NZ_CP069447:c4429255-4429198 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin