Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4192921..4193719 Replicon chromosome
Accession NZ_CP069447
Organism Escherichia coli strain FDAARGOS_1255

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag I6J85_RS19955 Protein ID WP_000854730.1
Coordinates 4193342..4193719 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag I6J85_RS19950 Protein ID WP_001285481.1
Coordinates 4192921..4193295 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J85_RS19910 4188896..4189348 + 453 WP_000682723.1 hypothetical protein -
I6J85_RS19915 4189466..4189699 + 234 WP_001213776.1 DUF905 family protein -
I6J85_RS19920 4189799..4190620 + 822 WP_001234359.1 DUF945 domain-containing protein -
I6J85_RS19925 4190620..4190865 + 246 WP_001164966.1 hypothetical protein -
I6J85_RS19930 4190959..4191432 + 474 WP_204083419.1 antirestriction protein -
I6J85_RS19935 4191448..4191924 + 477 WP_001186774.1 RadC family protein -
I6J85_RS19940 4191987..4192208 + 222 WP_000692315.1 DUF987 domain-containing protein -
I6J85_RS19945 4192227..4192871 + 645 WP_000086761.1 hypothetical protein -
I6J85_RS19950 4192921..4193295 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J85_RS19955 4193342..4193719 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
I6J85_RS19960 4193716..4194208 + 493 Protein_3894 hypothetical protein -
I6J85_RS19965 4194287..4195275 - 989 Protein_3895 IS630 family transposase -
I6J85_RS19970 4195423..4195611 - 189 Protein_3896 IS66 family transposase -
I6J85_RS19975 4195672..4196805 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
I6J85_RS19980 4197059..4198463 - 1405 Protein_3898 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4192921..4203408 10487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T190450 WP_000854730.1 NZ_CP069447:4193342-4193719 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T190450 NZ_CP091352:1141031-1141420 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT190450 WP_001285481.1 NZ_CP069447:4192921-4193295 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT190450 NZ_CP091352:1140767-1141024 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References