190448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2858748..2859310 Replicon chromosome
Accession NZ_CP069447
Organism Escherichia coli strain FDAARGOS_1255

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag I6J85_RS13395 Protein ID WP_000605675.1
Coordinates 2858748..2859026 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag I6J85_RS13400 Protein ID WP_000781370.1
Coordinates 2859026..2859310 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J85_RS13370 2854334..2854765 - 432 WP_000152307.1 peroxiredoxin OsmC -
I6J85_RS13375 2855110..2855325 + 216 WP_000495766.1 biofilm-dependent modulation protein -
I6J85_RS13380 2855427..2855564 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
I6J85_RS13385 2855721..2857418 + 1698 WP_000433460.1 malate dehydrogenase -
I6J85_RS13390 2857552..2858562 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
I6J85_RS13395 2858748..2859026 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J85_RS13400 2859026..2859310 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
I6J85_RS13405 2859539..2860192 - 654 WP_000045646.1 formate dehydrogenase-N subunit gamma -
I6J85_RS13410 2860185..2861069 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
I6J85_RS13415 2861082..2864129 - 3048 WP_011076399.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T190448 WP_000605675.1 NZ_CP069447:2858748-2859026 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T190448 NZ_CP091351:3718066-3718455 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT190448 WP_000781370.1 NZ_CP069447:2859026-2859310 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT190448 NZ_CP091351:3717802-3718059 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References