190438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2242032..2242863 Replicon chromosome
Accession NZ_CP069447
Organism Escherichia coli strain FDAARGOS_1255

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6J85_RS10515 Protein ID WP_000854814.1
Coordinates 2242032..2242406 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag I6J85_RS10520 Protein ID WP_001285586.1
Coordinates 2242495..2242863 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J85_RS10475 2237436..2238656 + 1221 WP_000343766.1 ISL3-like element ISEc53 family transposase -
I6J85_RS10480 2238713..2239186 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
I6J85_RS10485 2239384..2240442 + 1059 WP_001200890.1 FUSC family protein -
I6J85_RS10490 2240614..2240943 + 330 WP_000450409.1 DUF496 family protein -
I6J85_RS10495 2241044..2241226 - 183 WP_001016348.1 hypothetical protein -
I6J85_RS10500 2241280..2241426 + 147 Protein_2038 transposase domain-containing protein -
I6J85_RS10505 2241715..2241828 - 114 WP_001161660.1 DUF957 domain-containing protein -
I6J85_RS10510 2241841..2242035 - 195 WP_000988601.1 hypothetical protein -
I6J85_RS10515 2242032..2242406 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J85_RS10520 2242495..2242863 - 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J85_RS10525 2242937..2243158 - 222 WP_000692323.1 DUF987 domain-containing protein -
I6J85_RS10530 2243227..2243703 - 477 WP_001351157.1 RadC family protein -
I6J85_RS10535 2243719..2244204 - 486 WP_000213703.1 antirestriction protein -
I6J85_RS10540 2244295..2245116 - 822 WP_001234569.1 DUF945 domain-containing protein -
I6J85_RS10545 2245337..2245747 - 411 WP_000846704.1 hypothetical protein -
I6J85_RS10550 2245763..2246440 - 678 WP_001362823.1 hypothetical protein -
I6J85_RS10555 2246576..2247646 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2237436..2238656 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T190438 WP_000854814.1 NZ_CP069447:c2242406-2242032 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T190438 NZ_CP091345:c3207459-3207070 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT190438 WP_001285586.1 NZ_CP069447:c2242863-2242495 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT190438 NZ_CP091345:c3207723-3207466 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References