Detailed information of TA system TA190425

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4359556..4359814
• Replicon: chromosome
• Accession: NZ_CP069445
• Organism: Escherichia coli strain FDAARGOS_1251

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6J81_RS20650
• Protein ID: WP_000809168.1
• Coordinates: 4359556..4359708 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4359757..4359814 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J81_RS20630	4354801..4355514	-	714	WP_001102393.1	acidic protein MsyB	-
I6J81_RS20635	4355540..4355944	-	405	WP_000843692.1	DUF2541 family protein	-
I6J81_RS20640	4356316..4358232	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6J81_RS20645	4358321..4359451	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6J81_RS20650	4359556..4359708	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	4359757..4359814	+	58	-	-	Antitoxin
I6J81_RS20655	4360323..4361084	+	762	WP_001274832.1	hypothetical protein	-
I6J81_RS20660	4361104..4362597	+	1494	WP_001350365.1	sulfatase-like hydrolase/transferase	-
I6J81_RS20665	4362726..4363985	+	1260	WP_000494929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T190425 WP_000809168.1 NZ_CP069445:c4359708-4359556 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T190425 NZ_CP091335:3130738-3131127 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAACTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAACAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT190425 NZ_CP069445:4359757-4359814 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin