Detailed information of TA system TA190392

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2327308..2327530
• Replicon: chromosome
• Accession: NZ_CP069441
• Organism: Escherichia coli strain FDAARGOS_1261

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: I6J91_RS10995
• Protein ID: WP_000170745.1
• Coordinates: 2327308..2327415 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2327472..2327530 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J91_RS10970	2322561..2323313	-	753	WP_000279525.1	cellulose biosynthesis protein BcsQ	-
I6J91_RS10975	2323325..2323513	-	189	WP_001063314.1	YhjR family protein	-
I6J91_RS10980	2323786..2325357	+	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
I6J91_RS10985	2325354..2325545	+	192	WP_000988311.1	cellulose biosynthesis protein BcsF	-
I6J91_RS10990	2325542..2327221	+	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
I6J91_RS10995	2327308..2327415	-	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2327472..2327530	+	59	-	-	Antitoxin
I6J91_RS11000	2327891..2329162	+	1272	WP_001467807.1	amino acid permease	-
I6J91_RS11005	2329192..2330196	-	1005	WP_000103583.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6J91_RS11010	2330193..2331176	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
I6J91_RS11015	2331187..2332089	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T190392 WP_000170745.1 NZ_CP069441:c2327415-2327308 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T190392 NZ_CP091326:c3394237-3393827 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT190392 NZ_CP069441:2327472-2327530 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin