Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3800652..3800910 Replicon chromosome
Accession NZ_CP069438
Organism Escherichia coli strain FDAARGOS_1260

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I6J90_RS18500 Protein ID WP_000809168.1
Coordinates 3800652..3800804 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3800853..3800910 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J90_RS18480 3795897..3796610 - 714 WP_001102393.1 acidic protein MsyB -
I6J90_RS18485 3796636..3797040 - 405 WP_000843687.1 DUF2541 family protein -
I6J90_RS18490 3797412..3799328 + 1917 WP_000516135.1 molecular chaperone DnaK -
I6J90_RS18495 3799417..3800547 + 1131 WP_001118464.1 molecular chaperone DnaJ -
I6J90_RS18500 3800652..3800804 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3800853..3800910 + 58 - - Antitoxin
I6J90_RS18505 3801419..3802180 + 762 WP_001274832.1 hypothetical protein -
I6J90_RS18510 3802200..3803693 + 1494 WP_001468392.1 sulfatase-like hydrolase/transferase -
I6J90_RS18515 3803822..3805081 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T190365 WP_000809168.1 NZ_CP069438:c3800804-3800652 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T190365 NZ_CP091308:c1937688-1937410 [Burkholderia pyrrocinia]
ATGATCAGATCGTTCCGATGCAAGGATACCCAGTTGTTGTTTGCTGGAGCATCGCCCAGGCGTTTCCGCACGATCGAAAC
CGTTGCCTCCCGGAAACTGCAAATGGTCGCCGCTGCGAAAGAACTGCGCGATTTGCGGGCGCCGCCCGGCAACCGGCTCG
AAGCGTTGCAAGGCGATCGGGAAGGCCAGCACGGCATCCGCATCAACGAGCAATGGCGGATCTGTTTCGAATGGAGCGAC
GATGGCCCCACCCAGGTCGAGATCGTCGACTATCACTGA

Antitoxin


Download         Length: 58 bp

>AT190365 NZ_CP069438:3800853-3800910 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References