Detailed information of TA system TA190358

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2664383..2664605
• Replicon: chromosome
• Accession: NZ_CP069438
• Organism: Escherichia coli strain FDAARGOS_1260

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: I6J90_RS13050
• Protein ID: WP_000170745.1
• Coordinates: 2664383..2664490 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2664547..2664605 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J90_RS13025	2659636..2660388	-	753	WP_000279525.1	cellulose biosynthesis protein BcsQ	-
I6J90_RS13030	2660400..2660588	-	189	WP_001063314.1	YhjR family protein	-
I6J90_RS13035	2660861..2662432	+	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
I6J90_RS13040	2662429..2662620	+	192	WP_000988311.1	cellulose biosynthesis protein BcsF	-
I6J90_RS13045	2662617..2664296	+	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
I6J90_RS13050	2664383..2664490	-	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2664547..2664605	+	59	-	-	Antitoxin
I6J90_RS13055	2664966..2666237	+	1272	WP_001467807.1	amino acid permease	-
I6J90_RS13060	2666267..2667271	-	1005	WP_000103583.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6J90_RS13065	2667268..2668251	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
I6J90_RS13070	2668262..2669164	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T190358 WP_000170745.1 NZ_CP069438:c2664490-2664383 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T190358 NZ_CP091308:c104482-103586 [Burkholderia pyrrocinia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGACAGTTTCCCGAGCAGCGTTG
CGCAGCCGGTGCGGTGGGCACGATCGGATATCGCGAGGCCGGCGTGCAGCATGCGGGCCGCACGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACATGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTATGGCGCGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGTTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTTGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGACCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCAGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGTTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCTCA
AGCCGGTCATGCCGGATACGTGGAAGCGCCGGCCGTTTATTCCGCACTGATCGACACGTTTTGCCGTCAGTGCGATACGC
AGTGGGGGCTGGTATGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT190358 NZ_CP069438:2664547-2664605 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin