190343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 380817..381379 Replicon chromosome
Accession NZ_CP069438
Organism Escherichia coli strain FDAARGOS_1260

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag I6J90_RS02050 Protein ID WP_000605675.1
Coordinates 381101..381379 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag I6J90_RS02045 Protein ID WP_000781370.1
Coordinates 380817..381101 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J90_RS02030 377620..378504 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
I6J90_RS02035 378497..379150 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
I6J90_RS02040 379437..380783 + 1347 WP_000483766.1 IS4-like element IS4 family transposase -
I6J90_RS02045 380817..381101 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
I6J90_RS02050 381101..381379 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J90_RS02055 381565..382575 - 1011 WP_045232988.1 alcohol dehydrogenase AdhP -
I6J90_RS02060 382709..384406 - 1698 WP_000433462.1 malate dehydrogenase -
I6J90_RS02065 384562..384699 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
I6J90_RS02070 384801..385016 - 216 WP_000495766.1 biofilm-dependent modulation protein -
I6J90_RS02075 385361..385792 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 379455..380783 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T190343 WP_000605675.1 NZ_CP069438:c381379-381101 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T190343 NZ_CP091300:c2236187-2235903 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGAAGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT190343 WP_000781370.1 NZ_CP069438:c381101-380817 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT190343 NZ_CP091300:c2236419-2236177 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References