Detailed information of TA system TA190341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 436541..437150
• Replicon: chromosome
• Accession: NZ_CP069437
• Organism: Moraxella osloensis strain FDAARGOS_1202

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6J32_RS02460
• Protein ID: WP_204156606.1
• Coordinates: 436541..436879 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6J32_RS02465
• Protein ID: WP_160001813.1
• Coordinates: 436869..437150 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J32_RS02450	431871..433412	-	1542	WP_204156035.1	hypothetical protein	-
I6J32_RS02455	433438..436413	-	2976	WP_204156605.1	hypothetical protein	-
I6J32_RS02460	436541..436879	+	339	WP_204156606.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6J32_RS02465	436869..437150	+	282	WP_160001813.1	helix-turn-helix domain-containing protein	Antitoxin
I6J32_RS02470	437152..438135	-	984	WP_204156036.1	restriction endonuclease	-
I6J32_RS02475	438145..440361	-	2217	WP_204156037.1	FtsW/RodA/SpoVE family cell cycle protein	-
I6J32_RS02480	440411..441319	-	909	WP_204156038.1	RDD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-77)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12895.66 Da
• Isoelectric Point: 9.6239

>T190341 WP_204156606.1 NZ_CP069437:436541-436879 [Moraxella osloensis]
MHFIETPLFTKQIKELTDDDNYRDLQEDLIKNPQQGDLVQGTGGVRKTRWSSSSSTGKSGGMRIIYYYIEESGKFFMLLA
YPKSKKVTLSTEEKANLRKFTTAIKQVLHNEQ

Nucleotide

• Length: 339 bp

>T190341 NZ_CP091300:551525-551809 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10393.91 Da
• Isoelectric Point: 9.6928

>AT190341 WP_160001813.1 NZ_CP069437:436869-437150 [Moraxella osloensis]
MSNEFYDDLSLSLSQALSIARGETKPSRVFSYELPDIKAIRAKTGLTQAQFADKLNISSRTLQNWEQGTRHPTGATITLM
RLLEKKPELIALA

Nucleotide

• Length: 282 bp

>AT190341 NZ_CP091300:551287-551535 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACTGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA