Detailed information of TA system TA190338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1037124..1037636
• Replicon: chromosome
• Accession: NZ_CP069427
• Organism: Streptococcus oralis strain SF100

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A7T7IAZ6
• Locus tag: JQM34_RS04895
• Protein ID: WP_000924727.1
• Coordinates: 1037124..1037378 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JQM34_RS04900
• Protein ID: WP_192833023.1
• Coordinates: 1037382..1037636 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQM34_RS04860	1032220..1032534	-	315	WP_002874282.1	DNA-directed RNA polymerase subunit omega	-
JQM34_RS04865	1032559..1033185	-	627	WP_000775041.1	guanylate kinase	-
JQM34_RS04870	1033320..1034933	-	1614	WP_200370347.1	ribonuclease Y	-
JQM34_RS04875	1035003..1035305	-	303	WP_200371633.1	recombinase family protein	-
JQM34_RS04880	1035414..1036172	-	759	WP_200370349.1	hypothetical protein	-
JQM34_RS04885	1036188..1036328	-	141	WP_200370351.1	hypothetical protein	-
JQM34_RS04890	1036282..1036785	-	504	Protein_968	KilA-N domain-containing protein	-
JQM34_RS04895	1037124..1037378	-	255	WP_000924727.1	Txe/YoeB family addiction module toxin	Toxin
JQM34_RS04900	1037382..1037636	-	255	WP_192833023.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JQM34_RS04905	1037768..1038865	-	1098	WP_200370352.1	nucleotidyltransferase	-
JQM34_RS04910	1038875..1039615	-	741	WP_200370354.1	class I SAM-dependent methyltransferase	-
JQM34_RS04915	1039937..1040290	-	354	WP_007517833.1	ribosome silencing factor	-
JQM34_RS04920	1040291..1040884	-	594	WP_200370361.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
JQM34_RS04925	1040884..1041513	-	630	WP_200370363.1	nicotinate-nucleotide adenylyltransferase	-
JQM34_RS04930	1041565..1041876	-	312	WP_000060169.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10102.55 Da
• Isoelectric Point: 7.9716

>T190338 WP_000924727.1 NZ_CP069427:c1037378-1037124 [Streptococcus oralis]
MLLKFTEDAWADYCYWQTQDKKTLKRINKLIKDIQRDPFSGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSIAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T190338 NZ_CP091299:6576-6881 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9677.94 Da
• Isoelectric Point: 4.8430

>AT190338 WP_192833023.1 NZ_CP069427:c1037636-1037382 [Streptococcus oralis]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQAH
VIEE

Nucleotide

• Length: 255 bp

>AT190338 NZ_CP091299:6356-6574 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A7T7IAZ6